An impedimetric biosensor for COVID-19 serology test and modification of sensor performance via dielectrophoresis force유전영동력을 통한 센서 성능 수정 및 COVID-19 혈청학 테스트를 위한 방해계 바이오센서Article Published on 2022-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-S antibody antibody Antibody detection Antibody test assistance AuNP binding buffer causative agent caused Concentration conjugate coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 antibody COVID-19 serology test described detect Dielectrophoresis force digit faster gold Gold interdigitated electrodes Gold nanoparticles human sera IDE immunization impedance Impedimetric biosensor. limit of detection Modification morbidity and mortality non-specific phenomenon point-of-care solution Protein purified reached responses SARS-CoV-2 secondary antibody sensitivity sensor sera serology serology test serology tests serum severe acute respiratory syndrome Coronavirus Spectroscopy spike the disease therapeutic time-consuming [DOI] 10.1016/j.bios.2022.114476 PMC 바로가기 [Article Type] Article
Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infectionArticle Published on 2022-06-072022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome benefit boost cellular clinical trial convalescent coronavirus coronavirus disease COVID-19 COVID-19 vaccine dose doses driving effective vaccine Efficacy evaluated geometric mean titer GMT greater Heterologous highlighting homologous human sera humoral immune response immune response immunize low dose lower airways mice mRNA mRNA vaccine NAb neutralizing antibody non-human primate non-human primates offer pandemic populations prefusion prime-boost regimen Protective protective immunity provided reduction regimen regimens replicate rhesus macaque rhesus macaques RNA vaccines Safe SAM SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine spike glycoprotein Spread T cell response tested Translational immunology vaccination Vaccine viral replication [DOI] 10.1038/s41467-022-31005-z PMC 바로가기 [Article Type] Article
Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2BA.2 및 BA.3 SARS-CoV-2에 대한 Omicron BA.1의 교차 중화Article Published on 2022-05-262022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] COVID-19 vaccine cross-neutralization Frequency geometric mean titer GMT GMTs Heterologous homologous human sera implication initial neutralization neutralize Neutralizing omicron replaced responsible SARS-CoV-2 sera [DOI] 10.1038/s41467-022-30580-5 PMC 바로가기 [Article Type] Article
Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variantSARS-COV-2- 진화 및 COVID-19 환자의 인간 혈청은 SARS-COV-2 OMICRON 변이체의 RBD에 대한 결합 감소를 보여줍니다.Research Article Published on 2022-03-032022-09-10 Journal: BMC Medicine [Category] MERS, SARS, 변종, [키워드] ACE2 ACE2 binding addition analyzed angiotensin angiotensin-converting enzyme-2 Anti-RBD antibodies Anti-RBD antibody Antibody titer Antibody titers Beta Beta variant (B.1.351) Betacoronavirus binding BNT162b2 boost booster caused COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients D614G Delta Delta variant (B.1.617.2) Efficacy ELISA Evidence Evolution Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme-2 receptor (ACE2) human sera Immune escape insect cells less Mutation neutralization Neutralizing antibodies omicron Omicron variant Omicron variant (B.1.1.529) produced protocol RBD RBD binding RBD variants RBDs receptor Receptor-binding domain Receptor-binding domain (RBD) recipient reduced reduction in restored Result SARS-CoV-2 sera serum significantly lower Spike protein supplementary material the RBD the receptor-binding domain the spike protein vaccinated individuals vaccination vaccinee vaccinees variant Virus neutralization VoC VOCs wild type Wuhan Wuhan strain [DOI] 10.1186/s12916-022-02312-5 PMC 바로가기 [Article Type] Research Article
Neutralization of SARS-CoV-2 Variants by rVSV-ΔG-Spike-Elicited Human SeraBrief Report Published on 2022-02-142022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome Alpha Amino acid antibody BriLife® clinical trials comparable convalescent coronavirus COVID-19 delta variant Efficacy Human human sera Immunity less maintain Mutation mutations neutralization neutralization capacity neutralization titer Neutralizing antibody response platform reduction in SARS-CoV-2 SARS-CoV-2 vaccine spike mutation tested therapeutic Vaccine vaccinee variant variants vesicular stomatitis virus virus VoC VOCs VSV [DOI] 10.3390/vaccines10020291 PMC 바로가기 [Article Type] Brief Report
Sequentially immune-induced antibodies could cross-neutralize SARS-CoV-2 variants순차적으로 면역 유도된 항체는 SARS-CoV-2 변이체를 교차 중화할 수 있습니다Article Published on 2022-02-012022-09-11 Journal: Animal models and experimental medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody B.1.1.529 collected cross-neutralize cross-neutralize SARS-CoV-2 cross-neutralizing delta variant Delta variants demonstrated dose geometric mean geometric mean titer geometric mean titers GMT GMTs Human human sera Humoral immunity immune Immunity in vitro inactivated Inactivated vaccine lead Mutation neutralization Neutralization antibody neutralization titers Neutralizing activity neutralizing antibody omicron Omicron variant PiCoVacc Protein raised Recombinant protein reduction in SARS-CoV-2 SARS-CoV-2 variant sequentially immune. sera Spike protein target the spike protein vaccination Vaccine variant wild type ZF2001 [DOI] 10.1002/ame2.12216 PMC 바로가기 [Article Type] Article
In Planta Production of the Receptor-Binding Domain From SARS-CoV-2 With Human Blood Group A Glycan StructuresChemistry Published on 2022-02-012022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] ACE2 receptor Affect Analysis antibody Antigen approach benthamiana binding Blood Group Blood group antigen carbohydrate cellular co-expressed complex contribute CR3022 domain ENhance Epitopes functional glycan glycoengineering glycosylated glycosylation group Human human sera IgG immune evasion immunogenic in vivo individual Interaction Modification N-glycan Nicotiana benthamiana non-infected performed plants posttranslational modification Production purified RBD recombinant SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike protein sera serological assays shown Structure structures Subunit vaccine the RBD the SARS-CoV-2 variant Viral antigen viral envelope protein virus virus infection virus transmission [DOI] 10.3389/fchem.2021.816544 PMC 바로가기 [Article Type] Chemistry
Construction of the Enterococcal Strain Expressing Immunogenic Fragment of SARS-Cov-2 VirusPharmacology Published on 2022-01-052022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Antigen Bacteria construction demonstrated DNA fragment DNA sequencing domain Enterococcus experiment expression fragment of Frame Genome Gut health care systems human sera IgA response IgG response immune electron microscopy immune response Immunity immunoprecipitation Infection knowledge memory mucosal mucous membrane nasal Oral vaccine pandemic pathogen Patient Probiotic probiotic-based vaccines Protein RNA S protein SARS-CoV-2 strain T-cell therapeutic molecules Transcription vaccination Vaccine vaccine candidate [DOI] 10.3389/fphar.2021.807256 PMC 바로가기 [Article Type] Pharmacology
Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion PeptideSARS-CoV-2 융합 펩티드에 대한 인간 및 고양이 코로나바이러스 교차 반응성 항체의 기능 분석Immunology Published on 2022-01-052022-09-11 Journal: Frontiers in Immunology [Category] 변종, 진단, [키워드] Against Alpha alpha- analysis antibody Antigen being betacoronaviruses binding broadly neutralizing antibodies conserved coronavirus Coronavirus infection Coronaviruses COVID-19 patients cross-reactive antibody demonstrated disease elicited endemic human coronaviruses epitope exhibited Fc-mediated effector function Fc-mediated effector functions fusion fusion peptide Human human sera immunogenic Infection Kinetics N-terminal Neutralizing activity pepscan peptide Protective S2 subunit SARS-CoV-2 SARS-CoV-2 variants sera severity spike the SARS-CoV-2 therapeutic Viral viral spike [DOI] 10.3389/fimmu.2021.790415 PMC 바로가기 [Article Type] Immunology
A scalable and highly immunogenic virus-like particle-based vaccine against SARS-CoV-2SARS-CoV-2에 대한 확장 가능하고 면역원성이 높은 바이러스 유사 입자 기반 백신Article Published on 2022-01-012022-09-11 Journal: Allergy [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] added addition antibody Antibody Response Antibody responses Bacterial booster booster injections candidate vaccine caused centrifugation classical convalescent COVID-19 cross-reactive dose effective hand human sera hygiene immunogenic immunologically in some induce Injections long term Masks mice mutant Neutralizing Pandemics purification RBD RBM receptor-binding motif RNA SARS-CoV-2 stability the SARS-CoV-2 the vaccine Vaccine vaccine candidate Vaccines variants variants of concern virus virus-like particles virus-like particles. wearing masks while yield [DOI] 10.1111/all.15080 PMC 바로가기 [Article Type] Article